If you have a history of stomach issues, your healthcare provider may recommend avoiding NSAIDs altogether, if possible. They can cause stomach upset and raise the risk of stomach ulcers, although ibuprofen may cause less stomach irritation than aspirin. NSAID side effectsĪdvil Migraine and Excedrin Migraine both contain NSAIDs, which are known to be tough on the stomach. Otherwise, side effects are more medication specific. This is when you can experience a new or worsening headache or migraine on top of your current symptoms. This is because overusing these medications can cause medication overuse headaches (MOH) - also known as rebound headaches. If you find yourself using either medication more than 2 days per week, consider talking to your healthcare provider about other treatment options. When it comes to OTC migraine medications, there are some general side effects to keep in mind. What are common side effects of Advil Migraine and Excedrin Migraine?Īll medications, including OTC medications, can cause side effects to some degree. Time to start feeling relief: Excedrin Migraine may start working slightly faster for some people. Excedrin Migraine has three ingredients that work in different ways to relieve your symptoms. Excedrin Migraine, on the other hand, is a combination medication that contains aspirin, acetaminophen, and caffeine.ĭifferences in how they work: Advil Migraine only works one way, which is by blocking COX. But these key differences separate the two:ĭifferent ingredients: Advil Migraine contains ibuprofen. What are the key differences between Advil Migraine and Excedrin Migraine?Īdvil Migraine and Excedrin Migraine are comparable medications. If this is the case, your migraines may be better treated by a prescription migraine medication that comes in another form, such as a nasal spray or injection. This can be a problem if you’re experiencing significant nausea with your migraine. Keep in mind: Both medications are taken by mouth. But, there are still some things to consider before choosing between these two OTC products (we’ll get into side effects in a bit). The ingredients in Excedrin Migraine also kick in about 20 minutes faster. Research shows that the ingredients in Excedrin Migraine are more effective at reducing migraine pain than ibuprofen. Which works better for migraines: Advil Migraine or Excedrin Migraine?Īdvil Migraine and Excedrin Migraine are both effective for treating migraines. Caffeine also makes pain relievers like acetaminophen and aspirin more effective. Caffeine helps constrict those blood vessels, which helps relieve pain. Blood vessels sometimes dilate (become wider) before or during migraine attacks. Blood vessels inside your brain may also play a role in migraines. But it’s an effective pain reliever that’s thought to work by blocking pain signals in your central nervous system.Ĭaffeine works in another way. Unlike NSAIDs, acetaminophen doesn’t reduce inflammation. But what about acetaminophen? And why is there caffeine? So, it works the same way as the ibuprofen in Advil Migraine - it blocks COX to treat pain and swelling. How does Excedrin Migraine work?Īspirin is an NSAID. When you put all three of these ingredients together, they form a strategic combination that can be helpful in treating migraines. One of the key differences between Advil Migraine and Excedrin Migraine is that Excedrin Migraine is a combination medicine with three active ingredients: What is Excedrin Migraine?Įxcedrin Migraine is another oral OTC migraine medication. This contributes to inflammation control and pain relief. Without these enzymes, your body makes fewer prostaglandins. Ibuprofen and other NSAIDs work by blocking COX enzymes. Cyclooxygenase ( COX) is an enzyme (protein) that helps your body create prostaglandins. These inflammation-causing chemicals are released during an injury or illness and can lead to pain, redness, and swelling. Much of the pain you feel in your body, including migraine pain, can be linked to chemicals called prostaglandins. This comes in handy when treating many types of pain, including: It helps reduce inflammation (swelling) and pain. Regardless of branding, ibuprofen belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). But Advil Migraine comes as a liquid-filled capsule that helps it absorb into your body more quickly than traditional Advil tablets. Advil and Advil Migraine are oral medications that contain the same active ingredient and dosage: ibuprofen 200 mg.
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